Eljárás 4-klór-6-(szubsztituált-fenil)- pirimidinek elocombining double acute accentállításá ra

Translated title of the contribution: Synthesis of 4-chloro-6-(substituted-phenyl)-pyrimidines

Gábor Németh, Z. Varga, Zoltán Greff, G. Kéri, L. Őrfi

Research output: Contribution to journalArticle

Abstract

4-Phenylamino-6-phenyl-pyrimidine is a common core structure of several, important enzyme inhibitors. The common key intermediate of these compounds, 4-chloro-6-substituted phenyl pyrimidine, was synthesised by conventional methods without the application of special catalysts in contrary to the published methods. Here we present two different synthetic procedures for the preparation of the title compound. The results of these processes depend on the substituent of the 6-phenyl ring as it is demonstrated on the presented examples. The reactions can be performed via traditional heating either with microwave assistance.

Original languageHungarian
Pages (from-to)101-108
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume80
Issue number3
Publication statusPublished - 2010

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Pyrimidines
Enzyme Inhibitors
Microwaves
Heating
pyrimidine

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Eljárás 4-klór-6-(szubsztituált-fenil)- pirimidinek elocombining double acute accentállításá ra. / Németh, Gábor; Varga, Z.; Greff, Zoltán; Kéri, G.; Őrfi, L.

In: Acta Pharmaceutica Hungarica, Vol. 80, No. 3, 2010, p. 101-108.

Research output: Contribution to journalArticle

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AU - Greff, Zoltán

AU - Kéri, G.

AU - Őrfi, L.

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