Synthesis of 2‐14c‐labelled 3H‐1,4‐benzodiazepines

Z. S. Tegyey, G. Maksay, L. Ötvös

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

2‐14C‐oxazepam (7) 2‐14C‐(+)‐ and ‐(‐)‐7‐chloro‐1‐methyl‐5‐phenyl‐1,3,4,5‐tetrahydro‐3H‐1,4‐benzodiazepine‐2‐one (8a and 8b) as well as 2‐14‐7‐chloro‐4‐carbamoyl‐1‐methyl‐5‐phenyl‐1,3,4,5‐tetrahydro‐3H‐l,4‐benzodiazepine‐2‐one (9) were synthesised from carbobenzoxy‐glycine‐1‐14C. The overall radiochemical yields from carbobenzoxy‐glycine‐1‐14C were 28.9 % (7), 9.5 % (8a and 8b) and 25.3 % (9), respectively.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume16
Issue number3
DOIs
Publication statusPublished - 1979

Keywords

  • 1,4‐benzodiazepines
  • carbon‐14
  • synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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