Synthesis of 2-substituted pyrrolidine nitroxide radicals

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16 Citations (Scopus)

Abstract

Grignard reaction of nitrone 1 with arylmagnesium bromides afforded different pyrrolidine nitroxide radicals 2a-f, which were converted further to spin labelled ebselen 6, saccharine 11, phenols 5, 12, 13, quinone 16 and heterocycles 20, 21, 24. Paramagnetic sulfonyl chlorides 7a, 7b, 9a and methanethiosulfonate 25d capable of amino and thiol labelling, respectively, were also prepared.

Original languageEnglish
Pages (from-to)2039-2046
Number of pages8
JournalSynthesis
Issue number14
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Free radicals
  • Grignard reaction
  • Heterocycles
  • Oxidations
  • Phenols
  • Quinones
  • Reductions
  • Selenium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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