Various substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4- oxadiazoles were synthesized in high yields from the corresponding chloromethyl derivatives. Selective oxidation of the sulfides into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles by dimethyldioxirane under mild conditions was also demonstrated.
|Number of pages||11|
|Publication status||Published - Dec 1 2001|
- Nucleophilic substitution
ASJC Scopus subject areas
- Organic Chemistry