Synthesis of 2-(substituted-phenyl)-5-(aminomethyl)- and (thiomethyl)-1,3,4-oxadiazoles. Oxidation of thiomethyl-oxadiazole derivatives by dimethyldioxirane

Attila Kiss-Szikszai, T. Patonay, J. Jekó́

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Various substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4- oxadiazoles were synthesized in high yields from the corresponding chloromethyl derivatives. Selective oxidation of the sulfides into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles by dimethyldioxirane under mild conditions was also demonstrated.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalArkivoc
Volume2001
Issue number3
Publication statusPublished - 2001

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Oxadiazoles
Derivatives
Oxidation
Sulfides
1,3,4-oxadiazole
dimethyldioxirane

Keywords

  • 1,3,4-oxadiazole
  • Dimethyldioxirane
  • Nucleophilic substitution

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "Various substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4- oxadiazoles were synthesized in high yields from the corresponding chloromethyl derivatives. Selective oxidation of the sulfides into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles by dimethyldioxirane under mild conditions was also demonstrated.",
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T1 - Synthesis of 2-(substituted-phenyl)-5-(aminomethyl)- and (thiomethyl)-1,3,4-oxadiazoles. Oxidation of thiomethyl-oxadiazole derivatives by dimethyldioxirane

AU - Kiss-Szikszai, Attila

AU - Patonay, T.

AU - Jekó́, J.

PY - 2001

Y1 - 2001

N2 - Various substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4- oxadiazoles were synthesized in high yields from the corresponding chloromethyl derivatives. Selective oxidation of the sulfides into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles by dimethyldioxirane under mild conditions was also demonstrated.

AB - Various substituted 2-aryl-5-aminomethyl- and -5-thiomethyl-1,3,4- oxadiazoles were synthesized in high yields from the corresponding chloromethyl derivatives. Selective oxidation of the sulfides into 5-sulfinylmethyl and 5-sulfonylmethyl-1,3,4-oxadiazoles by dimethyldioxirane under mild conditions was also demonstrated.

KW - 1,3,4-oxadiazole

KW - Dimethyldioxirane

KW - Nucleophilic substitution

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