Synthesis of 2-dichloromethyl-2-methyl [2-14C]-1,3-dioxolane

I. Jablonkai, F. Dutka

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Abstract

The labelled compound was prepared by chlorination of [2-14C]acetone obtained from the barium salt of [1-14C]acetic acid by pyrolysis. The reaction product 1,1-dichloro [2-14C]acetone was converted to 2-dichloromethyl-2-methyl [2-14C]-1,3-dioxolane by condensation with ethylene glycol in the presence of thionyl chloride. Radiochemical yield: 62% based on [1-14C]acetic acid.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry Letters
Volume144
Issue number3
DOIs
Publication statusPublished - Feb 1 1990

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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