Heterokondenzalt kinazolonok szintezise: 1,2,4-triazino[6,1-b]-es 1,2,5- triazepino[2,3-b]kinazolonok elollitasa

Translated title of the contribution: Synthesis of 2-[4-(4-iodophenyl)-1-piperazinylmethyl]-1,3,4-oxadiazole and its potential application in the indirect iodination of carbonyl compounds

Kiss Árpád, Almási János, Szabó Mónika, Kökösi József, Hermecz István

Research output: Contribution to journalArticle

Abstract

In the course of the systhematic investigation of heterocondensed quinazolones derivatives of a new heterocyclic ring system, [1,2,5]triazepino[2,3-b]quinazolone have been developed as potential biologically active agents, which are new bioisoteric analogues of cholecystokinin antagonist diazepino[2,1-b]quinazolones. The authors worked out an original synthetic route for preparation of ring analogue [1,2,4]triazino[6,1-b]quinazoIines from intermediates of the synthesis, too. Starting 2-aIkyl-3-amino-quinazolones are easily prepared by reaction of 2- alkylbenzoxazone with hydrazine hydrate. In the next step bromination reaction of the alpha-methylene group of 2-alkyl-substituents gave a mono- bromo derivative as major product. In the reaction of the bromo compound with N-nucleophyles 2-alky-lamino-3-amino-quinazolones were obtained wich reacted with alpha-halogeno-carbonyl compounds and led to the tricyclic quinazolones in ring closure reaction. The structural properties of the heterocyclic compounds were characterized by UV-VIS and NMR data and molecular modelling calculation.

Original languageBulgarian
Pages (from-to)255-261
Number of pages7
JournalActa pharmaceutica Hungarica
Volume67
Issue number6
Publication statusPublished - Nov 1 1997

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ASJC Scopus subject areas

  • Pharmaceutical Science

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