Synthesis of 16-E-([aryl]idene)-3-methoxy-estrones by a palladium catalysed Mizoroki-Heck reaction

Steffen Riebe, Stefan Jopp, Peter Ehlers, E. Frank, G. Schneider, J. Wölfling, Alexander Villinger, Peter Langer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

16-E-Arylidene-3-methoxy-estrones were synthesized using a palladium catalysed Mizoroki-Heck reaction. This methodology tolerates various functional groups and gives the corresponding products in yields between 14 and 99%, which were strongly dependent on the electronic character of the aryl halides.

Original languageEnglish
Pages (from-to)2801-2803
Number of pages3
JournalTetrahedron Letters
Volume58
Issue number29
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Cross-coupling
  • Heck-reaction
  • Palladium
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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