Reaction of 6,6-dichloro-l-methyl-3-phosphabicyclo[3.1.0]hexane l-oxides 1 with silver nitrate in alcohols or in water leads to the regioisomers of alkoxy- or hydroxy-l,2,3,6-tetrahydrophosphorin l-oxides 2A and 2B or 3A and 3B. Each isomer consists of diastereoisomers. Water elimination from the hydroxy derivatives 3 results in the formation of the regioisomers of 1,2-dihydrophosphorin l-oxides 4A and 4B. Constitution and stereostructure of the compounds has been elucidated by1H,13C, and31P NMR spectroscopy.
ASJC Scopus subject areas
- Organic Chemistry