Synthesis of 1,2: 5,6-dianhydro-3,4-dideoxy-erythro- and D-threo-hexitol and their E-3-ENE derivatives

János Kuszmann, P. Sohár

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Starting from 1,2.5,6-di-O-isopropylidene-D-mannitol and -D-glucitol, respectively, D-threo- and erythro-hex-E-3-enitol were synthesized; these were hydrogenated to the 3,4-dideoxy compounds, which were converted into the corresponding 1,2:5,6-dianhydrides, possessing significantly different cytostatic activity. The D-threo- and erythro-E-3-ene diepoxides were also synthesized; they are unstable at room temperature and show no biological activity.

Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalCarbohydrate Research
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 1 1980

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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