Synthesis of α-hydroxyphosphonates and α-aminophosphonates

Zita Rádai, Nóra Zsuzsa Kiss, Zoltán Mucsi, G. Keglevich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Pudovik reaction between substituted benzaldehydes and dialkyl phosphites has been accomplished in a new, environmentally friendly way to afford the corresponding α-hydroxyphosphonates. During the substitution of α-hydroxyphosphonates by primary amines an unexpected neighboring group effect was found that promoted the formation of α-aminophosphonates. The phenomenon was justified by high-level quantum chemical calculations.

Original languageEnglish
Pages (from-to)1564-1565
Number of pages2
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume191
Issue number11-12
DOIs
Publication statusPublished - Dec 1 2016

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Keywords

  • crystallization
  • Pudovik reaction
  • theoretical calculations
  • α-aminophosphonates
  • α-Hydroxyphosphonates

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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