Synthesis of α-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals

Cecília P. Sár, Éva Hideg, Imre Vass, Kálmán Hideg

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14 Citations (Scopus)

Abstract

α-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the α-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number4
DOIs
Publication statusPublished - Feb 17 1998

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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