Synthesis of α-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals

Cecília P. Sár, É. Hideg, I. Vass, K. Hideg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

α-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the α-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number4
DOIs
Publication statusPublished - Feb 17 1998

Fingerprint

Spin Trapping
Hydroxyl Radical
Adamantane
Solubility
Water
nitrones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of α-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals. / Sár, Cecília P.; Hideg, É.; Vass, I.; Hideg, K.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 4, 17.02.1998, p. 379-384.

Research output: Contribution to journalArticle

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