Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents

Xianjin Cui, Domokos Mathe, Noémi Kovács, Ildikó Horváth, Maite Jauregui-Osoro, Rafael Torres Martin De Rosales, Gregory E.D. Mullen, Wilson Wong, Yong Yan, Dirk Krüger, Andrei N. Khlobystov, Maria Gimenez-Lopez, Mariann Semjeni, Krisztián Szigeti, Dániel S. Veres, Haizhou Lu, Ignacio Hernández, William P. Gillin, Andrea Protti, Katalin Kis PetikMark A. Green, Philip J. Blower

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM-1 s-1 at 3T, a high affinity to [18F]-fluoride or radiometal-bisphosphonate conjugates (e.g., 64Cu and 99mTc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalBioconjugate Chemistry
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 17 2016

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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    Cui, X., Mathe, D., Kovács, N., Horváth, I., Jauregui-Osoro, M., Torres Martin De Rosales, R., Mullen, G. E. D., Wong, W., Yan, Y., Krüger, D., Khlobystov, A. N., Gimenez-Lopez, M., Semjeni, M., Szigeti, K., Veres, D. S., Lu, H., Hernández, I., Gillin, W. P., Protti, A., ... Blower, P. J. (2016). Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents. Bioconjugate Chemistry, 27(2), 319-328. https://doi.org/10.1021/acs.bioconjchem.5b00338