Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co III, NiII, CuII and ZnII

Berta Holló, József Magyari, Vukosava Živković-Radovanović, Gordana Vučković, Zoran D. Tomić, Imre Miklós Szilágyi, G. Pokol, Katalin Meszaros Szecsenyi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6- diacetylpyridine (Hz2DAP) ligand with NiII, Co III, CuII and ZnII metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz2DAP and the obtained complexes [Co(Hz2DAP-H)Cl2]·MeOH, [Ni(Hz 2DAP-H)]Cl·MeOH, [Cu(Hz2DAP-H)Cl] and [Zn(Hz 2DAP-2H)]·H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with NiII, Co III and CuII show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz2DAP-2H)]·H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
JournalPolyhedron
Volume80
DOIs
Publication statusPublished - Sep 25 2014

Fingerprint

Hydrazones
hydrazones
Ligands
Candida
synthesis
Fungi
Escherichia coli
Single crystals
Decomposition
X ray diffraction
complex compounds
Metals
ligands
staphylococcus
fungi
Escherichia
phthalazine
decomposition
single crystals
diffraction

Keywords

  • Antimicrobial activity
  • Bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine
  • TG/MS

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Materials Chemistry
  • Physical and Theoretical Chemistry

Cite this

Holló, B., Magyari, J., Živković-Radovanović, V., Vučković, G., Tomić, Z. D., Szilágyi, I. M., ... Meszaros Szecsenyi, K. (2014). Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co III, NiII, CuII and ZnII. Polyhedron, 80, 142-150. https://doi.org/10.1016/j.poly.2014.03.007

Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co III, NiII, CuII and ZnII. / Holló, Berta; Magyari, József; Živković-Radovanović, Vukosava; Vučković, Gordana; Tomić, Zoran D.; Szilágyi, Imre Miklós; Pokol, G.; Meszaros Szecsenyi, Katalin.

In: Polyhedron, Vol. 80, 25.09.2014, p. 142-150.

Research output: Contribution to journalArticle

Holló, B, Magyari, J, Živković-Radovanović, V, Vučković, G, Tomić, ZD, Szilágyi, IM, Pokol, G & Meszaros Szecsenyi, K 2014, 'Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co III, NiII, CuII and ZnII', Polyhedron, vol. 80, pp. 142-150. https://doi.org/10.1016/j.poly.2014.03.007
Holló, Berta ; Magyari, József ; Živković-Radovanović, Vukosava ; Vučković, Gordana ; Tomić, Zoran D. ; Szilágyi, Imre Miklós ; Pokol, G. ; Meszaros Szecsenyi, Katalin. / Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co III, NiII, CuII and ZnII. In: Polyhedron. 2014 ; Vol. 80. pp. 142-150.
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