Synthesis and X-ray diffraction structures of novel half-sandwich Os(ii)-and Ru(ii)-hydroxamate complexes

Attila J. Godó, Attila Cs Bényei, Brian Duff, Denise A. Egan, Péter Buglyó

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Novel water soluble half-sandwich complexes of the general formulae [M(η 6-p-cym)(ha)] 2(CF 3SO 3) 2, [M(η 6-p-cym)(ha)Cl] or [M(η 6-p-cym) (ha)(py)]X (M = Os, Ru; ha = hydroxamate; py = pyridine; X = Cl - or CF 3SO 3 -), incorporating metal-containing entities and hydroxamates both with potential anti-proliferative features, were prepared and characterized by elemental analysis, spectroscopy (NMR, IR) and ESI mass spectrometry. The X-ray crystal structure of [Ru(η 6-p-cym) (μ-meaha)] 2(CF 3SO 3) 2 (5), [Os(η 6-p-cym)(meaha)Cl] (6), [Ru(η 6-p-cym)(phebha) Cl], (9), [Ru(η 6-p-cym)(bha)(py)](CF 3SO 3) (12) and [Ru(η 6-p-cym)(phebha)(py)](CF 3SO 3) (14), 6 is the first published structure of an organometallic Os(ii)-hydroxamate reported. The effect of size differences of the metal ions, the steric demand of the R C and R N substituents at the hydroxamate group and the type of the monodentate ligand co-present in the stoichiometry, along with the binding architecture of the half-sandwich metal(ii) hydroxamate complexes are discussed. A novel dinuclear, dihydroxo bridged complex [Os(η 6-p-cym)(py)(μ-OH)] 2(CF 3SO 3) 2 (16) is prepared and characterized by X-ray crystallography. Unexpected formation of a dinuclear oxo bridged Os II/Os VI complex [{Os(η 6-p-cym)(meaha)} (μ-O){Os(O)(meaha) 2}]Cl (17) occurs, and the crystal and molecular structure has been determined by X-ray method. Complexes 1, 5-8, 10 and 14 were tested for their in vitro cytotoxicity, using human-derived ovarian cancer cell lines (A2780 and A2780 cisR), and showed no anti-proliferative effect in the concentration range (0-200 μM) studied.

Original languageEnglish
Pages (from-to)1486-1495
Number of pages10
JournalRSC Advances
Issue number4
Publication statusPublished - Feb 21 2012


ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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