Abstract
Novel water soluble half-sandwich complexes of the general formulae [M(η 6-p-cym)(ha)] 2(CF 3SO 3) 2, [M(η 6-p-cym)(ha)Cl] or [M(η 6-p-cym) (ha)(py)]X (M = Os, Ru; ha = hydroxamate; py = pyridine; X = Cl - or CF 3SO 3 -), incorporating metal-containing entities and hydroxamates both with potential anti-proliferative features, were prepared and characterized by elemental analysis, spectroscopy (NMR, IR) and ESI mass spectrometry. The X-ray crystal structure of [Ru(η 6-p-cym) (μ-meaha)] 2(CF 3SO 3) 2 (5), [Os(η 6-p-cym)(meaha)Cl] (6), [Ru(η 6-p-cym)(phebha) Cl], (9), [Ru(η 6-p-cym)(bha)(py)](CF 3SO 3) (12) and [Ru(η 6-p-cym)(phebha)(py)](CF 3SO 3) (14), 6 is the first published structure of an organometallic Os(ii)-hydroxamate reported. The effect of size differences of the metal ions, the steric demand of the R C and R N substituents at the hydroxamate group and the type of the monodentate ligand co-present in the stoichiometry, along with the binding architecture of the half-sandwich metal(ii) hydroxamate complexes are discussed. A novel dinuclear, dihydroxo bridged complex [Os(η 6-p-cym)(py)(μ-OH)] 2(CF 3SO 3) 2 (16) is prepared and characterized by X-ray crystallography. Unexpected formation of a dinuclear oxo bridged Os II/Os VI complex [{Os(η 6-p-cym)(meaha)} (μ-O){Os(O)(meaha) 2}]Cl (17) occurs, and the crystal and molecular structure has been determined by X-ray method. Complexes 1, 5-8, 10 and 14 were tested for their in vitro cytotoxicity, using human-derived ovarian cancer cell lines (A2780 and A2780 cisR), and showed no anti-proliferative effect in the concentration range (0-200 μM) studied.
| Original language | English |
|---|---|
| Pages (from-to) | 1486-1495 |
| Number of pages | 10 |
| Journal | RSC Advances |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 21 2012 |
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ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemistry(all)
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Synthesis and X-ray diffraction structures of novel half-sandwich Os(ii)-and Ru(ii)-hydroxamate complexes. / Godó, Attila J.; Bényei, A.; Duff, Brian; Egan, Denise A.; Buglyó, P.
In: RSC Advances, Vol. 2, No. 4, 21.02.2012, p. 1486-1495.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and X-ray diffraction structures of novel half-sandwich Os(ii)-and Ru(ii)-hydroxamate complexes
AU - Godó, Attila J.
AU - Bényei, A.
AU - Duff, Brian
AU - Egan, Denise A.
AU - Buglyó, P.
PY - 2012/2/21
Y1 - 2012/2/21
N2 - Novel water soluble half-sandwich complexes of the general formulae [M(η 6-p-cym)(ha)] 2(CF 3SO 3) 2, [M(η 6-p-cym)(ha)Cl] or [M(η 6-p-cym) (ha)(py)]X (M = Os, Ru; ha = hydroxamate; py = pyridine; X = Cl - or CF 3SO 3 -), incorporating metal-containing entities and hydroxamates both with potential anti-proliferative features, were prepared and characterized by elemental analysis, spectroscopy (NMR, IR) and ESI mass spectrometry. The X-ray crystal structure of [Ru(η 6-p-cym) (μ-meaha)] 2(CF 3SO 3) 2 (5), [Os(η 6-p-cym)(meaha)Cl] (6), [Ru(η 6-p-cym)(phebha) Cl], (9), [Ru(η 6-p-cym)(bha)(py)](CF 3SO 3) (12) and [Ru(η 6-p-cym)(phebha)(py)](CF 3SO 3) (14), 6 is the first published structure of an organometallic Os(ii)-hydroxamate reported. The effect of size differences of the metal ions, the steric demand of the R C and R N substituents at the hydroxamate group and the type of the monodentate ligand co-present in the stoichiometry, along with the binding architecture of the half-sandwich metal(ii) hydroxamate complexes are discussed. A novel dinuclear, dihydroxo bridged complex [Os(η 6-p-cym)(py)(μ-OH)] 2(CF 3SO 3) 2 (16) is prepared and characterized by X-ray crystallography. Unexpected formation of a dinuclear oxo bridged Os II/Os VI complex [{Os(η 6-p-cym)(meaha)} (μ-O){Os(O)(meaha) 2}]Cl (17) occurs, and the crystal and molecular structure has been determined by X-ray method. Complexes 1, 5-8, 10 and 14 were tested for their in vitro cytotoxicity, using human-derived ovarian cancer cell lines (A2780 and A2780 cisR), and showed no anti-proliferative effect in the concentration range (0-200 μM) studied.
AB - Novel water soluble half-sandwich complexes of the general formulae [M(η 6-p-cym)(ha)] 2(CF 3SO 3) 2, [M(η 6-p-cym)(ha)Cl] or [M(η 6-p-cym) (ha)(py)]X (M = Os, Ru; ha = hydroxamate; py = pyridine; X = Cl - or CF 3SO 3 -), incorporating metal-containing entities and hydroxamates both with potential anti-proliferative features, were prepared and characterized by elemental analysis, spectroscopy (NMR, IR) and ESI mass spectrometry. The X-ray crystal structure of [Ru(η 6-p-cym) (μ-meaha)] 2(CF 3SO 3) 2 (5), [Os(η 6-p-cym)(meaha)Cl] (6), [Ru(η 6-p-cym)(phebha) Cl], (9), [Ru(η 6-p-cym)(bha)(py)](CF 3SO 3) (12) and [Ru(η 6-p-cym)(phebha)(py)](CF 3SO 3) (14), 6 is the first published structure of an organometallic Os(ii)-hydroxamate reported. The effect of size differences of the metal ions, the steric demand of the R C and R N substituents at the hydroxamate group and the type of the monodentate ligand co-present in the stoichiometry, along with the binding architecture of the half-sandwich metal(ii) hydroxamate complexes are discussed. A novel dinuclear, dihydroxo bridged complex [Os(η 6-p-cym)(py)(μ-OH)] 2(CF 3SO 3) 2 (16) is prepared and characterized by X-ray crystallography. Unexpected formation of a dinuclear oxo bridged Os II/Os VI complex [{Os(η 6-p-cym)(meaha)} (μ-O){Os(O)(meaha) 2}]Cl (17) occurs, and the crystal and molecular structure has been determined by X-ray method. Complexes 1, 5-8, 10 and 14 were tested for their in vitro cytotoxicity, using human-derived ovarian cancer cell lines (A2780 and A2780 cisR), and showed no anti-proliferative effect in the concentration range (0-200 μM) studied.
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U2 - 10.1039/c1ra00998b
DO - 10.1039/c1ra00998b
M3 - Article
VL - 2
SP - 1486
EP - 1495
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 4
ER -