Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels

Tamás Gyenes, Viktória Torma, Benjámin Gyarmati, Miklós Zrínyi

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Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory.

Original languageEnglish
Pages (from-to)733-744
Number of pages12
JournalActa Biomaterialia
Issue number3
Publication statusPublished - May 1 2008



  • Poly(aspartic acid)
  • Poly(succinimide)
  • Polymer gel
  • Swelling
  • pH sensitivity

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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