Synthesis and study of new paramagnetic resveratrol analogues

T. Kalai, Erzsébet Borza, Csenge Antus, Balázs Radnai, Gergely Gulyás-Fekete, Andrea Fehér, B. Sümegi, K. Hideg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNFα production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents.

Original languageEnglish
Pages (from-to)7311-7317
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number24
DOIs
Publication statusPublished - Dec 15 2011

Fingerprint

Scavenging
Molecules
Macrophages
Nitrites
Phenol
Lipopolysaccharides
Anti-Inflammatory Agents
Antioxidants
resveratrol
Derivatives
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid

Keywords

  • Anti-inflammatory agents
  • Antioxidants
  • Free radicals
  • Pd-catalysed reactions
  • Resveratrol

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis and study of new paramagnetic resveratrol analogues. / Kalai, T.; Borza, Erzsébet; Antus, Csenge; Radnai, Balázs; Gulyás-Fekete, Gergely; Fehér, Andrea; Sümegi, B.; Hideg, K.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 24, 15.12.2011, p. 7311-7317.

Research output: Contribution to journalArticle

Kalai T, Borza E, Antus C, Radnai B, Gulyás-Fekete G, Fehér A et al. Synthesis and study of new paramagnetic resveratrol analogues. Bioorganic and Medicinal Chemistry. 2011 Dec 15;19(24):7311-7317. https://doi.org/10.1016/j.bmc.2011.10.066
Kalai, T. ; Borza, Erzsébet ; Antus, Csenge ; Radnai, Balázs ; Gulyás-Fekete, Gergely ; Fehér, Andrea ; Sümegi, B. ; Hideg, K. / Synthesis and study of new paramagnetic resveratrol analogues. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 24. pp. 7311-7317.
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