Synthesis and study of new 4-quinazolinone inhibitors of the DNA repairenzyme poly(ADP-ribose) polymerase (PARP)

Gyozo Kulcsár, T. Kalai, E. Ősz, Cecília P. Sár, J. Jekó́, B. Sümegi, K. Hideg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

4-Quinazolinones modified with 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole or 2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine rings and their N-oxyl derivatives were synthesized and some of them evaluated for protecting activity against H2O2 induced cell death on WRL-68 human liver cell line. Compounds 15a, 15c and 15d exhibited remarkably inhibitory effects on PARP enzyme in vitro.

Original languageEnglish
Pages (from-to)121-131
Number of pages11
JournalArkivoc
Volume2003
Issue number5
Publication statusPublished - 2003

Fingerprint

Quinazolinones
Poly(ADP-ribose) Polymerases
Cell death
Liver
Cells
Derivatives
DNA
Enzymes
2,5-dihydro-1H-pyrrole

Keywords

  • Free radical scavengers
  • Nitroxides
  • PARP inhibitors
  • Quinazolines

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and study of new 4-quinazolinone inhibitors of the DNA repairenzyme poly(ADP-ribose) polymerase (PARP). / Kulcsár, Gyozo; Kalai, T.; Ősz, E.; Sár, Cecília P.; Jekó́, J.; Sümegi, B.; Hideg, K.

In: Arkivoc, Vol. 2003, No. 5, 2003, p. 121-131.

Research output: Contribution to journalArticle

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AU - Kalai, T.

AU - Ősz, E.

AU - Sár, Cecília P.

AU - Jekó́, J.

AU - Sümegi, B.

AU - Hideg, K.

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