Synthesis and structure of 5,5-diethoxycarbonyl-1-pyrroline N-oxide (DECPO). Application to superoxide radical trapping

Hakim Karoui, Jean Louis Clément, Antal Rockenbauer, Didier Siri, Paul Tordo

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27 Citations (Scopus)

Abstract

DECPO, a new analogue of EMPO was synthesized through a two-step synthetic pathway. Its structure and its application to trap superoxide were investigated. The ESR detection of the DECPO-OOH spin adduct is easy even at low concentration of superoxide. In comparison with DEPMPO, the trapping of superoxide with DECPO is faster and the detection of DECPO-OOH can be performed using a very low nitrone concentration (0.5mM).

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

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Keywords

  • DECPO
  • EMPO
  • Electron spin resonance
  • Nitrone
  • Spin trapping
  • Superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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