Synthesis and structure - Activity relationships of neuromuscular blocking agents

Zoltan Tuba, Sandor Maho, E. Sylvester Vizi

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

The first use of neuromuscular blocking agents (muscle relaxants) in clinical practice (1942) revolutionised the practice of anaesthesia and started the modern era of surgery. Since 1942 introduction of tubocurarine (18) neuromuscular blocking agents have been used routinely to provide skeletal muscle relaxation during surgical procedures allowing access to body cavities without hindrance from voluntary or reflex muscle movement. After the introduction of tubocurarine and the depolarizing suxamethonium chloride (4) (1949) several nondepolarizing steroidal and nonsteroidal neuromuscular blocking agents with different onset time and duration of effect were introduced e.g. gallamine triethiodide (1) (1949), methocurine (2) (1949), alcuronium chloride (3) (1963), pancuronium bromide (9) (1968), vecuronium bromide (11) (1982), pipecuronium bromide (10) (1982), atracurium besylate (5) (1982), doxacurium chloride (6) (1991), mivacurium chloride (8) (1992), rocuronium bromide (12) (1994) cisatracurium besylate (7) (1996), and rapacuronium bromide (13) (2000) (Fig. (1)). SZ-1677 (14) a steroid type nondepolarizing neuromuscular blocking agent under development (preclinical phase) (Fig. (2)).

Original languageEnglish
Pages (from-to)1507-1536
Number of pages30
JournalCurrent medicinal chemistry
Volume9
Issue number16
DOIs
Publication statusPublished - Jan 1 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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