Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri

Ágnes Kenéz, Zsombor Lestár, Béla Lenkey, Sándor Antus

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis of (±)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans (14053 and ATCC 10231), Candida inconspicua, Candida dubliniensis and Candida krusei.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalNatural Product Research
Volume22
Issue number5
DOIs
Publication statusPublished - Sep 4 2008

Keywords

  • Antifungal activity
  • Monotesone-A, synthesis
  • O-prenylated flavanones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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