Synthesis and structure-activity relationship of antifungal coniothyriomycin analogues

Karsten Krohn, Brigitta Elsässer, Sándor Antus, Krisztina Kónya, Eberhard Ammermann

Research output: Contribution to journalArticle

5 Citations (Scopus)


The structure of the antifungal metabolite coniothyriomycin was systematically modified by changing the acids of the open chain imide, modification of the hydrophobicity, variation in the degree of saturation, replacement of carbons by nitrogen or oxygen, and incorporation of the open chain molecule into cyclic arrangements. Structure-activity studies showed that antifungal activity was retained by replacement of phenylacetic acids by benzoic acids in the imide structure but diminished by hydrogenation of the fumaric ester part.

Original languageEnglish
Pages (from-to)296-305
Number of pages10
JournalJournal of Antibiotics
Issue number3
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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