Synthesis and stereochemistry of spiropyrazolines

Gabor Tóth, Áron Szöllösy, Albert Lévai, George Kotovych

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Spiropyrazolines have been synthesized by 1,3-dipolar cycloaddition of an 2-arylidene-1 -tetralone, 3-arylidene-chromanones, -1-thiochromanones, and -flavanones with diazomethane. The relative configuration and stereochemistry of the products have been determined by means of one-dimensional difference N.O.E. measurements. It is shown that ring-closure reaction is regioselective, yielding stereohomogeneous spiropyrazolines in one step.

Original languageEnglish
Pages (from-to)1895-1898
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number12
Publication statusPublished - Jan 1 1986


ASJC Scopus subject areas

  • Chemistry(all)

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