Synthesis and stereochemical study of cis- and trans-1-(3′-substituted-propyl)benzo[a]quinolizidine

Jenõ Kóbor, P. Sohár, F. Fülöp

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

From 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline with methyl or ethyl acrylate or with acrylonitrile, via Michael addition products, cis- and trans-1-(3′-substituted-propyl)benzo[a]quinolizidinones and quinolizidines were prepared. The relative configurations and the predominant conformations were determined by means of 1H and 13C NMR spectroscopy, with the application of DR, DNOE and 2D HSC measurements.

Original languageEnglish
Pages (from-to)4873-4886
Number of pages14
JournalTetrahedron
Volume50
Issue number16
DOIs
Publication statusPublished - Apr 18 1994

Fingerprint

Quinolizidines
Acrylonitrile
Nuclear magnetic resonance spectroscopy
Conformations
Magnetic Resonance Spectroscopy
methyl acrylate
G 1616
ethyl acrylate
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis and stereochemical study of cis- and trans-1-(3′-substituted-propyl)benzo[a]quinolizidine. / Kóbor, Jenõ; Sohár, P.; Fülöp, F.

In: Tetrahedron, Vol. 50, No. 16, 18.04.1994, p. 4873-4886.

Research output: Contribution to journalArticle

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