Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

Lorenzo Tei, Z. Baranyai, Mauro Botta, Laura Piscopo, Silvio Aime, Giovanni B. Giovenzana

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.

Original languageEnglish
Pages (from-to)2361-2368
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number13
DOIs
Publication statusPublished - 2008

Fingerprint

Alkaline Earth Metals
Lanthanoid Series Elements
alkaline earth metals
Egtazic Acid
conjugation
Macromolecules
Thermodynamics
macromolecules
Functional groups
Metal ions
metal ions
Ions
Derivatives
thermodynamics
acids
Acids
synthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives. / Tei, Lorenzo; Baranyai, Z.; Botta, Mauro; Piscopo, Laura; Aime, Silvio; Giovenzana, Giovanni B.

In: Organic and Biomolecular Chemistry, Vol. 6, No. 13, 2008, p. 2361-2368.

Research output: Contribution to journalArticle

Tei, Lorenzo ; Baranyai, Z. ; Botta, Mauro ; Piscopo, Laura ; Aime, Silvio ; Giovenzana, Giovanni B. / Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives. In: Organic and Biomolecular Chemistry. 2008 ; Vol. 6, No. 13. pp. 2361-2368.
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