Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

Lorenzo Tei, Zsolt Baranyai, Mauro Botta, Laura Piscopo, Silvio Aime, Giovanni B. Giovenzana

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.

Original languageEnglish
Pages (from-to)2361-2368
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number13
DOIs
Publication statusPublished - Jun 25 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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