Synthesis and semisynthesis of some structural elements of oligo-mannose type N-glycoproteins

Zoltán Szurmai, Lóránt Jánossy, Zoltán Szilágyi, Károly Vékey

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

For the construction of N-glycoprotein glycan chains, valuable potential glycosyl donors, O-α-D-mannopyranosyl-(1→2)-α-D-mannopyranose octaacetate (19) and O-α-D-mannopyranosyl-(1→2)-O-α-D-mannopyranosyl-(1→2)- α-D-mannopyranose undecaacetate (20) were obtained in gram-scale by the acetylation and subsequent partial acetolysis of baker's yeast, without the isolation of mannan. The acetolytic products were investigated by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Octaacetates of mannobiose (1→3) (11) and (1→6) (17) were chemically synthesized.

Original languageEnglish
Pages (from-to)417-437
Number of pages21
JournalJournal of Carbohydrate Chemistry
Volume17
Issue number3
DOIs
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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