Synthesis and resolution of a Tolperisone metabolite

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The synthesis and resolution of a Tolperisone metabolite ((3'-hydroxy- 4'-methylphenyl)-2-methyl-3-(piperidine-1-yl)-1-propane-1-one, M1) is described. Racemic M1 was subjected to resolution by the enantiomers of camphor-10-sulfonic acid. Absolute configuration was determined by X-ray diffraction analysis. Enantiomeric excesses were determined by 1H NMR spectroscopy. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1323-1329
Number of pages7
JournalTetrahedron Asymmetry
Volume11
Issue number6
DOIs
Publication statusPublished - Apr 7 2000

Fingerprint

Tolperisone
Camphor
Propane
Sulfonic Acids
Enantiomers
metabolites
Metabolites
X-Ray Diffraction
X ray diffraction analysis
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
camphor
piperidine
Acids
sulfonic acid
enantiomers
synthesis
propane
nuclear magnetic resonance
configurations

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Synthesis and resolution of a Tolperisone metabolite. / Bálint, J.; Hell, Z.; Markovits, Imre; Párkányí, L.; Fogassy, E.

In: Tetrahedron Asymmetry, Vol. 11, No. 6, 07.04.2000, p. 1323-1329.

Research output: Contribution to journalArticle

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