Synthesis and preliminary thermodynamic investigation of hypoxanthine- containing peptide nucleic acids

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A new, hypoxanthine-containing PNA monomer, PNAs and complementary DNAs were designed, produced and investigated by thermal denaturation studies in order to find the analogue of inosine at PNAs [1]. Thermodynamic data were determined with the van't Hoff method [2, 3]. The measured and computational values were correlated.

Original languageEnglish
Pages (from-to)1131-1133
Number of pages3
JournalNucleosides and Nucleotides
Issue number4-5
Publication statusPublished - Jan 1 1999


ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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