Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

E. Kasztreiner, G. Rabloczky, N. Makk, P. Mátyus, E. Diesler, A. Tegdes, J. Kosáry, K. Czakó, S. Gyürki, G. Cseh, M. Kürthy, L. Jaszlits

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2 Citations (Scopus)

Abstract

Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume25
Issue number4
DOIs
Publication statusPublished - May 1990

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Keywords

  • 4-(substituted amino)-6,7-dihydropyrimido[5,4-b][1,4]-oxazin-7-(8H)-ones
  • positive inotropic activity

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Kasztreiner, E., Rabloczky, G., Makk, N., Mátyus, P., Diesler, E., Tegdes, A., Kosáry, J., Czakó, K., Gyürki, S., Cseh, G., Kürthy, M., & Jaszlits, L. (1990). Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones. European Journal of Medicinal Chemistry, 25(4), 333-341. https://doi.org/10.1016/0223-5234(90)90117-L