Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

E. Kasztreiner, G. Rabloczky, N. Makk, P. Mátyus, E. Diesler, A. Tegdes, J. Kosáry, K. Czakó, S. Gyürki, G. Cseh, M. Kürthy, L. Jaszlits

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume25
Issue number4
DOIs
Publication statusPublished - 1990

Fingerprint

Amrinone
Pharmacology
Derivatives
N-dodecyl-L-lysine amide

Keywords

  • 4-(substituted amino)-6,7-dihydropyrimido[5,4-b][1,4]-oxazin-7-(8H)-ones
  • positive inotropic activity

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones. / Kasztreiner, E.; Rabloczky, G.; Makk, N.; Mátyus, P.; Diesler, E.; Tegdes, A.; Kosáry, J.; Czakó, K.; Gyürki, S.; Cseh, G.; Kürthy, M.; Jaszlits, L.

In: European Journal of Medicinal Chemistry, Vol. 25, No. 4, 1990, p. 333-341.

Research output: Contribution to journalArticle

Kasztreiner, E, Rabloczky, G, Makk, N, Mátyus, P, Diesler, E, Tegdes, A, Kosáry, J, Czakó, K, Gyürki, S, Cseh, G, Kürthy, M & Jaszlits, L 1990, 'Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones', European Journal of Medicinal Chemistry, vol. 25, no. 4, pp. 333-341. https://doi.org/10.1016/0223-5234(90)90117-L
Kasztreiner, E. ; Rabloczky, G. ; Makk, N. ; Mátyus, P. ; Diesler, E. ; Tegdes, A. ; Kosáry, J. ; Czakó, K. ; Gyürki, S. ; Cseh, G. ; Kürthy, M. ; Jaszlits, L. / Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones. In: European Journal of Medicinal Chemistry. 1990 ; Vol. 25, No. 4. pp. 333-341.
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AU - Mátyus, P.

AU - Diesler, E.

AU - Tegdes, A.

AU - Kosáry, J.

AU - Czakó, K.

AU - Gyürki, S.

AU - Cseh, G.

AU - Kürthy, M.

AU - Jaszlits, L.

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