Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives

Anton Ivanov, Sebastian Boldt, Zaib Un Nisa, Syed Jawad Ali Shah, Peter Ehlers, Alexander Villinger, G. Schneider, J. Wölfling, Qamar Rahman, Jamshed Iqbal, Peter Langer

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6 Citations (Scopus)

Abstract

A range of 3-alkynylated 3-deoxy-estrones were prepared by Sonogashira reactions and transformed into estrone derived diones and quinoxalines. The alkynylated estrones and their derivatives exhibit significant biological activity as alkaline phosphatase inhibitors. The mode of action was illustrated based on docking studies.

Original languageEnglish
Pages (from-to)11118-11127
Number of pages10
JournalRSC Advances
Volume6
Issue number14
DOIs
Publication statusPublished - 2016

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ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Ivanov, A., Boldt, S., Nisa, Z. U., Ali Shah, S. J., Ehlers, P., Villinger, A., Schneider, G., Wölfling, J., Rahman, Q., Iqbal, J., & Langer, P. (2016). Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives. RSC Advances, 6(14), 11118-11127. https://doi.org/10.1039/c5ra25558a