Synthesis and pharmacological study of new 3,4-dihydro-2H,6H-pyrimido-[2,1-b][1,3]thiazines

D. Bózsing, P. Sohár, G. Gigler, G. Kovács

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

A series of racemic pyrimido-thiazine derivatives was synthesized and many of their in vivo activities found to be comparable to acetylsalicylic acid and aminophenazone in an antiinflammatory model and an antipyretic test. Analogues 7a and 7e are the most potent in rat carrageenin and yeast fever assays. These compounds did not inhibit prostaglandin biosynthesis in vitro.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume31
Issue number9
DOIs
Publication statusPublished - Jan 1 1996

Keywords

  • Antiinflammatory
  • Antipyretic
  • Pyrimidothiazine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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