Synthesis and pharmacological study of new 3,4-dihydro-2H,6H-pyrimido-[2,1-b][1,3]thiazines

D. Bózsing, P. Sohár, G. Gigler, G. Kovács

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A series of racemic pyrimido-thiazine derivatives was synthesized and many of their in vivo activities found to be comparable to acetylsalicylic acid and aminophenazone in an antiinflammatory model and an antipyretic test. Analogues 7a and 7e are the most potent in rat carrageenin and yeast fever assays. These compounds did not inhibit prostaglandin biosynthesis in vitro.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume31
Issue number9
DOIs
Publication statusPublished - 1996

Fingerprint

Thiazines
Aminopyrine
Antipyretics
Carrageenan
Biosynthesis
Yeast
Aspirin
Prostaglandins
Rats
Assays
Anti-Inflammatory Agents
Fever
Yeasts
Pharmacology
Derivatives
In Vitro Techniques

Keywords

  • Antiinflammatory
  • Antipyretic
  • Pyrimidothiazine

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and pharmacological study of new 3,4-dihydro-2H,6H-pyrimido-[2,1-b][1,3]thiazines. / Bózsing, D.; Sohár, P.; Gigler, G.; Kovács, G.

In: European Journal of Medicinal Chemistry, Vol. 31, No. 9, 1996, p. 663-668.

Research output: Contribution to journalArticle

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