Synthesis and pharmacological activity of C(1)- and N(2)-substituted

Ralf Plate, Rutger J F Nivard, Harry C J Ottenheijm, J. Kardos, M. Simonyi

Research output: Contribution to journalArticle

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Abstract

A series of C(1) as well as N(2)-hetero-substituted β-carbolines has been synthesized from indoles via N-hydroxytryptophan derivatives (Schemes I and II). Preliminary pharmacodynamical data are provided (Tabel I). Of the β-carbolines 4,5,14-16 prepared, the compounds 4,5 and 14 show appreciable in vitro affinity towards the benzodiazepine receptor.

Original languageEnglish
Pages (from-to)3105-3114
Number of pages10
JournalHeterocycles
Volume24
Issue number11
Publication statusPublished - Nov 1 1986

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Carbolines
Pharmacology
Indoles
5-Hydroxytryptophan
GABA-A Receptors
Derivatives
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Plate, R., Nivard, R. J. F., Ottenheijm, H. C. J., Kardos, J., & Simonyi, M. (1986). Synthesis and pharmacological activity of C(1)- and N(2)-substituted. Heterocycles, 24(11), 3105-3114.

Synthesis and pharmacological activity of C(1)- and N(2)-substituted. / Plate, Ralf; Nivard, Rutger J F; Ottenheijm, Harry C J; Kardos, J.; Simonyi, M.

In: Heterocycles, Vol. 24, No. 11, 01.11.1986, p. 3105-3114.

Research output: Contribution to journalArticle

Plate, R, Nivard, RJF, Ottenheijm, HCJ, Kardos, J & Simonyi, M 1986, 'Synthesis and pharmacological activity of C(1)- and N(2)-substituted', Heterocycles, vol. 24, no. 11, pp. 3105-3114.
Plate R, Nivard RJF, Ottenheijm HCJ, Kardos J, Simonyi M. Synthesis and pharmacological activity of C(1)- and N(2)-substituted. Heterocycles. 1986 Nov 1;24(11):3105-3114.
Plate, Ralf ; Nivard, Rutger J F ; Ottenheijm, Harry C J ; Kardos, J. ; Simonyi, M. / Synthesis and pharmacological activity of C(1)- and N(2)-substituted. In: Heterocycles. 1986 ; Vol. 24, No. 11. pp. 3105-3114.
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