Synthesis and pharmacodynamic investigation of new isoguvacine analogues with benzoquinolizine skeleton

Gábor Blaskó, Julianna Kardos, Eszter Baitz-Gács, Miklós Simonyi, Csaba Szántay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Stereoisomer hydroxy-esters 1 =5 = - 1 =9 = as well as isoguvacine analogue 2 =0 = with benzo[a]quinolizine skeleton have been prepared via regioselective Dieckmann condensation of diester 9 = followed by subsequent reduction and E2-elimination. Compounds 1 =6 = and 2 =0 = have shown a considerable in vitro activity at the GABA/benzodiazepine receptor complex.

Original languageEnglish
Pages (from-to)2887-2900
Number of pages14
JournalHeterocycles
Volume24
Issue number10
Publication statusPublished - Oct 1 1986

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this