Stereoisomer hydroxy-esters 1 =5 = - 1 =9 = as well as isoguvacine analogue 2 =0 = with benzo[a]quinolizine skeleton have been prepared via regioselective Dieckmann condensation of diester 9 = followed by subsequent reduction and E2-elimination. Compounds 1 =6 = and 2 =0 = have shown a considerable in vitro activity at the GABA/benzodiazepine receptor complex.
|Number of pages||14|
|Publication status||Published - Oct 1 1986|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry