Synthesis and opioid binding properties of new β-funaltrexamine (β-FNA) analogues

Csaba Simon, Sándor Hosztafi, Sándor Makleit, A. Márki, S. Benyhe, A. Borsodi

Research output: Contribution to journalArticle

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Abstract

Several 6β-chloroacetamido- and 6β-monomethylfumaramido-4,5α-epoxy-7,8-didehydro-morphinans and their analogues with saturated ring C were prepared and their binding affinities to μ, δ and κ opioid receptors determined. Subtype specifity has also been evaluated by the aid of labeled selective ligands.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalMedicinal Chemistry Research
Volume7
Issue number4
Publication statusPublished - 1997

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Morphinans
Opioid Receptors
Opioid Analgesics
Ligands

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis and opioid binding properties of new β-funaltrexamine (β-FNA) analogues. / Simon, Csaba; Hosztafi, Sándor; Makleit, Sándor; Márki, A.; Benyhe, S.; Borsodi, A.

In: Medicinal Chemistry Research, Vol. 7, No. 4, 1997, p. 251-258.

Research output: Contribution to journalArticle

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AU - Borsodi, A.

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