Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids

András Keglevich, Vivian Zsiros, Péter Keglevich, Áron Szigetvári, Miklós Dékány, Csaba Szántay, E. Mernyák, J. Wölfling, László Hazai

Research output: Contribution to journalArticle

Abstract

10-Aminovindoline and 17-desacetylvindoline were coupled with 5α-dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.

Original languageEnglish
Pages (from-to)959-967
Number of pages9
JournalCurrent Organic Chemistry
Volume23
Issue number8
DOIs
Publication statusPublished - Jan 1 2019

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Vinca Alkaloids
Nandrolone
Dihydrotestosterone
Succinic Acid
Steroids
Cells
vindoline

Keywords

  • Antitumor activity
  • Hybrid molecules
  • Steroid
  • Succinate linker
  • Vinca alkaloids
  • Vindoline

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Keglevich, A., Zsiros, V., Keglevich, P., Szigetvári, Á., Dékány, M., Szántay, C., ... Hazai, L. (2019). Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids. Current Organic Chemistry, 23(8), 959-967. https://doi.org/10.2174/1385272823666190614113218

Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids. / Keglevich, András; Zsiros, Vivian; Keglevich, Péter; Szigetvári, Áron; Dékány, Miklós; Szántay, Csaba; Mernyák, E.; Wölfling, J.; Hazai, László.

In: Current Organic Chemistry, Vol. 23, No. 8, 01.01.2019, p. 959-967.

Research output: Contribution to journalArticle

Keglevich, A, Zsiros, V, Keglevich, P, Szigetvári, Á, Dékány, M, Szántay, C, Mernyák, E, Wölfling, J & Hazai, L 2019, 'Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids', Current Organic Chemistry, vol. 23, no. 8, pp. 959-967. https://doi.org/10.2174/1385272823666190614113218
Keglevich A, Zsiros V, Keglevich P, Szigetvári Á, Dékány M, Szántay C et al. Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids. Current Organic Chemistry. 2019 Jan 1;23(8):959-967. https://doi.org/10.2174/1385272823666190614113218
Keglevich, András ; Zsiros, Vivian ; Keglevich, Péter ; Szigetvári, Áron ; Dékány, Miklós ; Szántay, Csaba ; Mernyák, E. ; Wölfling, J. ; Hazai, László. / Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids. In: Current Organic Chemistry. 2019 ; Vol. 23, No. 8. pp. 959-967.
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