Synthesis and gastroprotective activity of 4h-pyrido[1,2-a]pyrimidin-4- ones

I. Hermecz, J. Sipos, L. Vasvari-Debreczy, K. Gyires, Z. Kapui

Research output: Contribution to journalArticle

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Abstract

The cytoprotective effect of different types of 4h-pyrido[1,2- a]pyrimidin-4-one derivatives was investigated. Short synthesis of the investigated compounds was depicted. The gastroprotective effect was determied against acidified ethanol induced mucosal lesions in rats. The most effective compounds belong to unsaturated 4-oxo-4h-pyrido[1,2-a]pyrimidine- 3-carboxamide derivatives, and the most active one contains a methyl group in position 6 and a cyclopentyl group on the nitrogen of the carboxamide group. Further pharmacological, biochemical and clinical studies may justify, that the representative of this type of compounds may be useful as profilactic agents against gastric damage caused by non-steroidal antiinflammatory agents.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalActa Physiologica Hungarica
Volume80
Issue number1-4
Publication statusPublished - 1992

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Gastrointestinal Agents
Non-Steroidal Anti-Inflammatory Agents
Ethanol
Nitrogen
Pharmacology
pyrimidine
Clinical Studies

ASJC Scopus subject areas

  • Physiology

Cite this

Synthesis and gastroprotective activity of 4h-pyrido[1,2-a]pyrimidin-4- ones. / Hermecz, I.; Sipos, J.; Vasvari-Debreczy, L.; Gyires, K.; Kapui, Z.

In: Acta Physiologica Hungarica, Vol. 80, No. 1-4, 1992, p. 225-235.

Research output: Contribution to journalArticle

Hermecz, I, Sipos, J, Vasvari-Debreczy, L, Gyires, K & Kapui, Z 1992, 'Synthesis and gastroprotective activity of 4h-pyrido[1,2-a]pyrimidin-4- ones', Acta Physiologica Hungarica, vol. 80, no. 1-4, pp. 225-235.
Hermecz, I. ; Sipos, J. ; Vasvari-Debreczy, L. ; Gyires, K. ; Kapui, Z. / Synthesis and gastroprotective activity of 4h-pyrido[1,2-a]pyrimidin-4- ones. In: Acta Physiologica Hungarica. 1992 ; Vol. 80, No. 1-4. pp. 225-235.
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