The efficient synthesis of all‐cis‐[220.127.116.11]fenestrane (2) from the readily available intermediate 3 allowed the electron‐diffraction analysis of 2. This structure analysis revealed long CC bonds in the central C(C)4 fragment and a twist‐envelope conformation for the four cyclopentane substructures. The four bridgehead H‐atoms are in a synclinal rather than an ecliptic position with an approximate D2 symmetry of 2. Planarizing distortions are evident from the opposite bond angles at the central C‐atom being 116.2 ± 0.5° with the remaining four being 103.7 ± 0.2°.
ASJC Scopus subject areas
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry