Synthesis and cytotoxic activity of N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates

János Botyánszki, József Bódi, Ian J. Stratford, H. Süli-Vargha

Research output: Contribution to journalArticle

Abstract

As analogs of the widely used anti-tumor agents, N-(2-chloroethyl)-N-nitrosoureas, N-(2-chloroethyl)-N-nitroureas and N-2-chloroethyl)-N-nitrocarbamates were synthesized by nitration following the reaction of the appropriate amines or alcohols with 2-chloroethyl isocyanate. All tested compounds exert cytotoxic effect with IC50 values of 10-4 to 10-6 M and most of them show somewhat higher cytotoxicity in nitrogen than in air. (C) 1999 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalAnti-Cancer Drugs
Volume10
Issue number10
Publication statusPublished - 1999

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Inhibitory Concentration 50
Amines
Nitrogen
Air
Alcohols
Neoplasms
2-chloroethyl isocyanate

Keywords

  • Cytotoxicity
  • N-(2-chloroethyl)-N-nitro
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research
  • Oncology

Cite this

Synthesis and cytotoxic activity of N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates. / Botyánszki, János; Bódi, József; Stratford, Ian J.; Süli-Vargha, H.

In: Anti-Cancer Drugs, Vol. 10, No. 10, 1999, p. 903-909.

Research output: Contribution to journalArticle

Botyánszki, János ; Bódi, József ; Stratford, Ian J. ; Süli-Vargha, H. / Synthesis and cytotoxic activity of N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates. In: Anti-Cancer Drugs. 1999 ; Vol. 10, No. 10. pp. 903-909.
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