As analogs of the widely used anti-tumor agents, N-(2-chloroethyl)-N-nitrosoureas, N-(2-chloroethyl)-N-nitroureas and N-2-chloroethyl)-N-nitrocarbamates were synthesized by nitration following the reaction of the appropriate amines or alcohols with 2-chloroethyl isocyanate. All tested compounds exert cytotoxic effect with IC50 values of 10-4 to 10-6 M and most of them show somewhat higher cytotoxicity in nitrogen than in air. (C) 1999 Lippincott Williams and Wilkins.
|Number of pages||7|
|Publication status||Published - Dec 1 1999|
ASJC Scopus subject areas
- Pharmacology (medical)
- Cancer Research