SZUBSZTITUALT PIRIMIDO[6,1-A]IZOKINOLINOK ELOALLITASA

Translated title of the contribution: Synthesis and conformational analysis of pyrimido[6,1-a]isoquinoline derivatives

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Abstract

(1R*,αS*) and (1R*,αR*) 1-(1'-ethoxycarbonylethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (10, 11), its carboxamide (12a,b, 14a,b) and hydrazide (16a,b, 19a,b) derivatives and 1-, 3-, 4- and 6-substituted 9,10-dimethoxypyrimido[6,1-a]isoquinolin-2-ones (13a,b, 15a,b, 18a,b, 21a,b, 22a,b, 24a,b) were prepared from cis and trans-1-ethoxcycarbonylmethyl-3-methyl-6,7-dimethoxy-1,2,3,4 -tetrahydroisoquinoline (6,7). The structures of the products were determined by 1H and 13C NMR spectroscopy.

Original languageHungarian
Pages (from-to)347-351
Number of pages5
JournalGyogyszereszet
Volume39
Issue number5
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Pharmacology

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