Synthesis and circular dichroism of optically active 1,3-disubstituted isochromans of dopamine D4 antagonist activity

Gábor Kerti, T. Kurtán, K. Kövér, Sándor Sólyom, István Greiner, S. Antus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The C-1 epimers of the 3-methyl-6,7-dimethoxy analogues of the D 4 antagonist sonepiprazole 1b and 5-HT1D agonist PNU-109291 1a containing both the isochroman and p-methoxyphenylpiperazine chromophores were prepared in order to study the applicability of circular dichroism for the assignment of the configuration of 1,3-disubstituted isochromans and test their dopamine D4 antagonist activity.

Original languageEnglish
Pages (from-to)2356-2360
Number of pages5
JournalTetrahedron Asymmetry
Volume21
Issue number19
DOIs
Publication statusPublished - Oct 7 2010

Fingerprint

Serotonin 5-HT1 Receptor Agonists
dopamine
Dichroism
Chromophores
chromophores
dichroism
Dopamine
analogs
synthesis
configurations
PNU 109291
sonepiprazole

ASJC Scopus subject areas

  • Organic Chemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

Synthesis and circular dichroism of optically active 1,3-disubstituted isochromans of dopamine D4 antagonist activity. / Kerti, Gábor; Kurtán, T.; Kövér, K.; Sólyom, Sándor; Greiner, István; Antus, S.

In: Tetrahedron Asymmetry, Vol. 21, No. 19, 07.10.2010, p. 2356-2360.

Research output: Contribution to journalArticle

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