Synthesis and chromatographic study of methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-β-d-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-β-d-ribofuranoside

Attila Gyepes, Richárd Schäffer, Gábor Bajor, Ágnes Woller, Péter Fodor

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis of two riboside-containing arsenic compounds, methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-β-d-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-β-d- ribofuranoside is presented in this paper. Intermediates and final products of the synthesis were examined by gas chromatography and thin layer chromatography. The purity of the products was assessed by NMR spectroscopy. Trimethylsilylation was used to volatilise sugar compounds and thus use of the costly HPLC-MS technique was avoided. The results affirmed the presence of tautomers in case of arsenosugars.

Original languageEnglish
Pages (from-to)2655-2661
Number of pages7
JournalPolyhedron
Volume27
Issue number12
DOIs
Publication statusPublished - Aug 21 2008

Keywords

  • Arsenosugars
  • Gas chromatography
  • Methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-β-d-ribofuranoside
  • Methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-β-d-ribofuranoside
  • Thin-layer chromatography
  • Trimethylsilylation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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