Synthesis and chiroptical properties of 5α-cholest-2-eno[2,3- ]pyrazine derivatives

György Hajós, Günther Snatzke

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The steroidal pyrazine 5 has been synthesized from 5α-cholestane-2,3-dione, and its cd has been compared with that of octahydronaphtopyrazine 7 with C2-symmetry. The n→x* - Cotton effects of the parent compound have the same signs and magnitudes as for the homochirally analogous steroid, whereas the k→x* - Cotton effects differ. On the other hand, pyrazines containing substituents nonsymmetrically attached to the chromophore show very similar Cotton effects. Assignment of transitions for the 2,3-dihydropyrazine chromophore could be made by comparison of the cd and uv spectra.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalHeterocycles
Volume28
Issue number2
DOIs
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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