Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method

Teodóra Nagyné-Kovács, Levente Studnicka, Annamária Kincses, G. Spengler, Mónika Molnár, Mária Tolner, István Endre Lukács, Imre M. Szilágyi, G. Pokol

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study presents the preparation of pure, Sr and Mg-doped hydroxyapatite (HAP) by precipitation. Sr-doped HAPs (SrHAPs) and Mg-doped HAPs (MgHAPs) were fabricated with Sr molar ratio of 2, 4, 6, 8, 12% and Mg molar ratio of 2, 4%, respectively. Ca(NO3)2, Sr(NO3)2, Mg(NO3)2, (NH4)2HPO4 were used as starting materials, the Ca/P molar ratio was kept 1.67 during every synthesis and a 900 °C heat treatment was conducted to enhance the crystallinity. All of the products were analyzed by XRD, SEM and EDX, moreover lattice parameters and crystallite size calculations were performed to prove the ion incorporation into the crystal structure. The HAP structure was maintained when 2 and 4 Sr and 2 Mg % were applied and EDX confirmed the Sr and Mg content in these samples. In all other cases, various Sr and Mg-containing phases (Sr0.13Ca2.87(PO4)2, Ca2P2O7, Mg0.29Ca2.71(PO4)2) were identified while the HAP structure disappeared. It was shown that lattice parameters and the unit cell volume of Sr-doped HAPs increased slightly compared to pure HAP due to the bigger radius of Sr2+ than Ca2+. As the ionic radius of Mg2+ is smaller than Ca2+, we demonstrated the distortion in the unit cell. Crystallite sizes increased as the amount of Sr and Mg raised. SEM experiments demonstrated that ion incorporation had little influence on the morphology, i.e. pure, Sr or Mg-doped HAPs were mostly homogenous, constituted of strongly sintered nanometer sized grains. Antimicrobial tests indicated that SrHAP with 4 Sr % and MgHAP with 2% Mg had positive effect on the inhibition of cell viability.

Original languageEnglish
JournalCeramics International
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Durapatite
Hydroxyapatite
Crystallite size
Lattice constants
Energy dispersive spectroscopy
Ions
Scanning electron microscopy
Crystal structure
Heat treatment
Cells
Experiments

Keywords

  • Antibacterial activity
  • Calcination
  • Crystallite size
  • Lattice parameters
  • Sr and Mg-doped hydroxyapatite

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method. / Nagyné-Kovács, Teodóra; Studnicka, Levente; Kincses, Annamária; Spengler, G.; Molnár, Mónika; Tolner, Mária; Lukács, István Endre; Szilágyi, Imre M.; Pokol, G.

In: Ceramics International, 01.01.2018.

Research output: Contribution to journalArticle

Nagyné-Kovács, Teodóra ; Studnicka, Levente ; Kincses, Annamária ; Spengler, G. ; Molnár, Mónika ; Tolner, Mária ; Lukács, István Endre ; Szilágyi, Imre M. ; Pokol, G. / Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method. In: Ceramics International. 2018.
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abstract = "This study presents the preparation of pure, Sr and Mg-doped hydroxyapatite (HAP) by precipitation. Sr-doped HAPs (SrHAPs) and Mg-doped HAPs (MgHAPs) were fabricated with Sr molar ratio of 2, 4, 6, 8, 12{\%} and Mg molar ratio of 2, 4{\%}, respectively. Ca(NO3)2, Sr(NO3)2, Mg(NO3)2, (NH4)2HPO4 were used as starting materials, the Ca/P molar ratio was kept 1.67 during every synthesis and a 900 °C heat treatment was conducted to enhance the crystallinity. All of the products were analyzed by XRD, SEM and EDX, moreover lattice parameters and crystallite size calculations were performed to prove the ion incorporation into the crystal structure. The HAP structure was maintained when 2 and 4 Sr and 2 Mg {\%} were applied and EDX confirmed the Sr and Mg content in these samples. In all other cases, various Sr and Mg-containing phases (Sr0.13Ca2.87(PO4)2, Ca2P2O7, Mg0.29Ca2.71(PO4)2) were identified while the HAP structure disappeared. It was shown that lattice parameters and the unit cell volume of Sr-doped HAPs increased slightly compared to pure HAP due to the bigger radius of Sr2+ than Ca2+. As the ionic radius of Mg2+ is smaller than Ca2+, we demonstrated the distortion in the unit cell. Crystallite sizes increased as the amount of Sr and Mg raised. SEM experiments demonstrated that ion incorporation had little influence on the morphology, i.e. pure, Sr or Mg-doped HAPs were mostly homogenous, constituted of strongly sintered nanometer sized grains. Antimicrobial tests indicated that SrHAP with 4 Sr {\%} and MgHAP with 2{\%} Mg had positive effect on the inhibition of cell viability.",
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AU - Nagyné-Kovács, Teodóra

AU - Studnicka, Levente

AU - Kincses, Annamária

AU - Spengler, G.

AU - Molnár, Mónika

AU - Tolner, Mária

AU - Lukács, István Endre

AU - Szilágyi, Imre M.

AU - Pokol, G.

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N2 - This study presents the preparation of pure, Sr and Mg-doped hydroxyapatite (HAP) by precipitation. Sr-doped HAPs (SrHAPs) and Mg-doped HAPs (MgHAPs) were fabricated with Sr molar ratio of 2, 4, 6, 8, 12% and Mg molar ratio of 2, 4%, respectively. Ca(NO3)2, Sr(NO3)2, Mg(NO3)2, (NH4)2HPO4 were used as starting materials, the Ca/P molar ratio was kept 1.67 during every synthesis and a 900 °C heat treatment was conducted to enhance the crystallinity. All of the products were analyzed by XRD, SEM and EDX, moreover lattice parameters and crystallite size calculations were performed to prove the ion incorporation into the crystal structure. The HAP structure was maintained when 2 and 4 Sr and 2 Mg % were applied and EDX confirmed the Sr and Mg content in these samples. In all other cases, various Sr and Mg-containing phases (Sr0.13Ca2.87(PO4)2, Ca2P2O7, Mg0.29Ca2.71(PO4)2) were identified while the HAP structure disappeared. It was shown that lattice parameters and the unit cell volume of Sr-doped HAPs increased slightly compared to pure HAP due to the bigger radius of Sr2+ than Ca2+. As the ionic radius of Mg2+ is smaller than Ca2+, we demonstrated the distortion in the unit cell. Crystallite sizes increased as the amount of Sr and Mg raised. SEM experiments demonstrated that ion incorporation had little influence on the morphology, i.e. pure, Sr or Mg-doped HAPs were mostly homogenous, constituted of strongly sintered nanometer sized grains. Antimicrobial tests indicated that SrHAP with 4 Sr % and MgHAP with 2% Mg had positive effect on the inhibition of cell viability.

AB - This study presents the preparation of pure, Sr and Mg-doped hydroxyapatite (HAP) by precipitation. Sr-doped HAPs (SrHAPs) and Mg-doped HAPs (MgHAPs) were fabricated with Sr molar ratio of 2, 4, 6, 8, 12% and Mg molar ratio of 2, 4%, respectively. Ca(NO3)2, Sr(NO3)2, Mg(NO3)2, (NH4)2HPO4 were used as starting materials, the Ca/P molar ratio was kept 1.67 during every synthesis and a 900 °C heat treatment was conducted to enhance the crystallinity. All of the products were analyzed by XRD, SEM and EDX, moreover lattice parameters and crystallite size calculations were performed to prove the ion incorporation into the crystal structure. The HAP structure was maintained when 2 and 4 Sr and 2 Mg % were applied and EDX confirmed the Sr and Mg content in these samples. In all other cases, various Sr and Mg-containing phases (Sr0.13Ca2.87(PO4)2, Ca2P2O7, Mg0.29Ca2.71(PO4)2) were identified while the HAP structure disappeared. It was shown that lattice parameters and the unit cell volume of Sr-doped HAPs increased slightly compared to pure HAP due to the bigger radius of Sr2+ than Ca2+. As the ionic radius of Mg2+ is smaller than Ca2+, we demonstrated the distortion in the unit cell. Crystallite sizes increased as the amount of Sr and Mg raised. SEM experiments demonstrated that ion incorporation had little influence on the morphology, i.e. pure, Sr or Mg-doped HAPs were mostly homogenous, constituted of strongly sintered nanometer sized grains. Antimicrobial tests indicated that SrHAP with 4 Sr % and MgHAP with 2% Mg had positive effect on the inhibition of cell viability.

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KW - Crystallite size

KW - Lattice parameters

KW - Sr and Mg-doped hydroxyapatite

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