Synthesis and characterization of some collagen sequence analogs

J. Botyanszki, J. Bodi, J. Kajtar, U. Ragnarsson, G. Pogany, A. Jeney, H. Suli-Vargha

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Abstract

Some analogs of natural collagen sequences (773-779) were synthesized. The peptides were hydrolyzed at the Gly-Ile bond not only by crude collagenase isolated from normal rat liver, but also by the bacterial Clostridium histolyticum collagenase. The reason for this unusual cleavage site in the latter case may lie in the unordered secondary structure of the substrates measured by CD spectroscopy.

Original languageEnglish
Pages (from-to)525-534
Number of pages10
JournalBiochemistry International
Volume27
Issue number3
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Biochemistry

Cite this

Botyanszki, J., Bodi, J., Kajtar, J., Ragnarsson, U., Pogany, G., Jeney, A., & Suli-Vargha, H. (1992). Synthesis and characterization of some collagen sequence analogs. Biochemistry International, 27(3), 525-534.