Synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds

Bálint Sinkó, Melinda Pálfi, S. Béni, J. Kökösi, K. Takács-Novák

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.

Original languageEnglish
Pages (from-to)824-833
Number of pages10
JournalMolecules
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Diamide
cornea
Ceramides
fibroblasts
strata
anhydrides
chemical properties
lipids
acids
Anhydrides
Fibroblasts
synthesis
matrices
Cornea
Chemical properties
Skin
Cells
Lipids
tartaric acid
In Vitro Techniques

Keywords

  • Apoptosis
  • Ceramide-analogues
  • Tartradiamides
  • Transdermal penetration

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds. / Sinkó, Bálint; Pálfi, Melinda; Béni, S.; Kökösi, J.; Takács-Novák, K.

In: Molecules, Vol. 15, No. 2, 02.2010, p. 824-833.

Research output: Contribution to journalArticle

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