Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids

Sándor Bátori, Géza Tímári, István Koczka, István Hermecz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New racemic N-(1-aziridino)-6-flouro-7-(4-methylpiperazin-1-yl)-4(1H)- quinolone-3-carboxylic acids (9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro- organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1).

Original languageEnglish
Pages (from-to)1507-1510
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number13
DOIs
Publication statusPublished - Jul 9 1996

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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