Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids

Sándor Bátori, Géza Tímári, István Koczka, I. Hermecz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New racemic N-(1-aziridino)-6-flouro-7-(4-methylpiperazin-1-yl)-4(1H)- quinolone-3-carboxylic acids (9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro- organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1).

Original languageEnglish
Pages (from-to)1507-1510
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number13
DOIs
Publication statusPublished - Jul 9 1996

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Nalidixic Acid
Quinolones
Ciprofloxacin
Carboxylic Acids
4-quinolone-3-carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids. / Bátori, Sándor; Tímári, Géza; Koczka, István; Hermecz, I.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 13, 09.07.1996, p. 1507-1510.

Research output: Contribution to journalArticle

Bátori, Sándor ; Tímári, Géza ; Koczka, István ; Hermecz, I. / Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 13. pp. 1507-1510.
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