Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I

Katalin Gulácsi, György Litkei, Sándor Antus, Csaba Szántay, László L. Darkó, Judith Szelényi, György Haskó, Szilveszter E. Vizi

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4 Citations (Scopus)

Abstract

A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-α production in the plasma in comparison with that of cabenegrin A-I (1a).

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalArchiv der Pharmazie
Volume334
Issue number2
DOIs
Publication statusPublished - Mar 28 2001

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Keywords

  • Cabenegrin
  • Structure-activity relationship
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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