Synthesis and biological activity of N-acylphenothiazines

Noboru Motohashi, Masami Kawase, Setsuo Saito, Teruo Kurihara, Kazue Satoh, Hideki Nakashima, Mariappan Premanathan, Rieko Arakaki, Hiroshi Sakagami, J. Molnár

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previous studies have demonstrated the relationship between radical intensity and cytotoxic activity in water-soluble compounds. This relationship was investigated in lipophilic compounds. Several N-acylphenothiazines showed higher cytotoxic activity against human leukemic and squamous carcinoma cell lines than phenothiazine, the parent compound. Electron spin resonance (ESR) spectroscopy showed that these active compounds produced much lower amounts of radicals than phenothiazine. Several compounds failed to inhibit the cytopathic effects of human immunodeficiency virus (HIV) infection in MT-4 cells. It suggested that the radical-mediated-mechanisms has not involved in the induction of cytotoxic activity by lipophilic compounds, such as N-acylphenothiazines. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 2000

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Electron Spin Resonance Spectroscopy
Virus Diseases
Human Activities
Squamous Cell Carcinoma
HIV
Cell Line
Water
phenothiazine
acylphenothiazine

Keywords

  • Anti-HIV activity
  • Free radicals
  • HL-60 cells
  • HSC-2 cells
  • N-Acylphenothiazines
  • Water-solubility

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Synthesis and biological activity of N-acylphenothiazines. / Motohashi, Noboru; Kawase, Masami; Saito, Setsuo; Kurihara, Teruo; Satoh, Kazue; Nakashima, Hideki; Premanathan, Mariappan; Arakaki, Rieko; Sakagami, Hiroshi; Molnár, J.

In: International Journal of Antimicrobial Agents, Vol. 14, No. 3, 04.2000, p. 203-207.

Research output: Contribution to journalArticle

Motohashi, N, Kawase, M, Saito, S, Kurihara, T, Satoh, K, Nakashima, H, Premanathan, M, Arakaki, R, Sakagami, H & Molnár, J 2000, 'Synthesis and biological activity of N-acylphenothiazines', International Journal of Antimicrobial Agents, vol. 14, no. 3, pp. 203-207. https://doi.org/10.1016/S0924-8579(99)00156-9
Motohashi N, Kawase M, Saito S, Kurihara T, Satoh K, Nakashima H et al. Synthesis and biological activity of N-acylphenothiazines. International Journal of Antimicrobial Agents. 2000 Apr;14(3):203-207. https://doi.org/10.1016/S0924-8579(99)00156-9
Motohashi, Noboru ; Kawase, Masami ; Saito, Setsuo ; Kurihara, Teruo ; Satoh, Kazue ; Nakashima, Hideki ; Premanathan, Mariappan ; Arakaki, Rieko ; Sakagami, Hiroshi ; Molnár, J. / Synthesis and biological activity of N-acylphenothiazines. In: International Journal of Antimicrobial Agents. 2000 ; Vol. 14, No. 3. pp. 203-207.
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