Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst, István Zupkó, Ágnes Berényi, Gerhard F. Ecker, Uwe Rinner

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

Original languageEnglish
Pages (from-to)6948-6951
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number24
DOIs
Publication statusPublished - Dec 15 2009

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Keywords

  • Anticancer drug
  • Colchicine
  • Combretastatin
  • Stilbene
  • Tubulin binding

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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