Synthesis and antitumor activity of 1-[2-(chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas as potent anticancer agents

Noboru Motohashi, Masami Kawase, Teruo Kurihara, Anikó Hevér, Szilvia Nagy, Imre Ocsocvszki, Masaru Tanaka, Joseph Molnár

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35 Citations (Scopus)

Abstract

10-[N-(Phthalimido)alkyl]-2-substituted-10H-phenothiazines and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas were synthesized and found to have antiproliferative effects on human HEp-2 and L5178Y cell cultures. The multi-drug resistant subline of mouse lymphoma was sensitive to the reversal effects of some 10-[N-(phthalimido)alkyl]-2-substituted-10H-phenothiazines, while 1-(2-chloro-ethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1-ureas were less effective but had a similar degree of antiproliferative effect on both cell lines.

Original languageEnglish
Pages (from-to)2525-2532
Number of pages8
JournalAnticancer research
Volume16
Issue number5 A
Publication statusPublished - Sep 1 1996

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Keywords

  • 10-[N-(phthalimido)alkyl]-2-substituted-10H-phenothiazines,1-(2-
  • Antitumor activity
  • Structure-activity relationship
  • chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1-ureas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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