10-[N-(Phthalimido)alkyl]-2-substituted-10H-phenothiazines and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas were synthesized and found to have antiproliferative effects on human HEp-2 and L5178Y cell cultures. The multi-drug resistant subline of mouse lymphoma was sensitive to the reversal effects of some 10-[N-(phthalimido)alkyl]-2-substituted-10H-phenothiazines, while 1-(2-chloro-ethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1-ureas were less effective but had a similar degree of antiproliferative effect on both cell lines.
|Number of pages||8|
|Issue number||5 A|
|Publication status||Published - Sep 1 1996|
- Antitumor activity
- Structure-activity relationship
ASJC Scopus subject areas
- Cancer Research