Synthesis and antihypertensive activity of novel 6-substituted-3-pyridazinylhydrazones

G. Szilagyi, E. Kasztreiner, P. Mátyus

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The synthesis and hypotensive properties of a series of 6-substituted-3-pyridazinylhydrazones are described. The most active compound of the series. 1-(6-morpholino-3-pyridazinyl)-2-[1-(tert-butoxycarbonyl)-2-propylidene] hydrazine, is a more potent hypotensive agent than hydralazine with a longer duration of action and a lower toxicity. Structure-activity relationships are discussed.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume19
Issue number2
Publication statusPublished - 1984

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hydrazine
Morpholinos
Hydralazine
Structure-Activity Relationship
Antihypertensive Agents
Toxicity
Thermodynamic properties

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and antihypertensive activity of novel 6-substituted-3-pyridazinylhydrazones. / Szilagyi, G.; Kasztreiner, E.; Mátyus, P.

In: European Journal of Medicinal Chemistry, Vol. 19, No. 2, 1984, p. 111-117.

Research output: Contribution to journalArticle

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